Published on April 7, 2018
(Source: PRN-Physician Recommended Nutriceuticals®)

• PRN AREDS2® plus formula with 25mg of zinc which is confirmed effective in the AREDS2 study
• PRN AREDS2® plus formula contains the more absorbable natural form of Vitamin E
• Full B-complex (B6, B9, B12) enhancement for neuroprotective effect

What is AREDS2?

AREDS2 is a follow up study sponsored by the National Eye Institute (NEI) to determine if adding further nutritional ingredients to the original AREDS formula would provide better nutritional support for patient’s macular health. This was a five-year study with over 4,200 participants. One focus of the study was to see if beta-carotene should stay in the formula and to analyze the benefits of adding lutein and zeaxanthin. Findings showed that removing beta-carotene and adding lutein and zeaxanthin provided the best results. In addition, results of AREDS2 suggested that lowering the amount of zinc provided the same benefits as the original AREDS formula with a higher amount of zinc.

    The doses of zinc used in the AREDS study (80mg per day of zinc in the form of zinc oxide for 6.3 years, on average) have been associated with a significant increase in hospitalizations for genitourinary causes, raising the possibility that chronically high intakes of zinc adversely affect some aspects of urinary physiology.1
    The tolerable upper level of daily zinc intake is 40 mg.2
    Long-term intakes above the Upper Limit increase the risk of adverse health effects. The Upper Limits do not apply to individuals receiving zinc for medical treatment, but such individuals should be under the care of a physician who monitors them for adverse health effects.
    Less potential for stomach irritation
    The original AREDS report (a ten year study) showed gastrointestinal issues were more common in participants who took zinc (80 mg) than a placebo.
    There is less concern for copper deficiency anemia.

Macular Vitamin Benefits is formulated based on the results of the AREDS2 study.
PRN Macular Vitamin Benefits
At PRN, we formulate our products based on the latest scientific evidence to make sure our customers receive the best possible nutriceutical products. When the results of the AREDS2 study were released, we partnered with top ophthalmologists to formulate an updated vitamin product for our customers that included unique enhancements they felt would further benefit eye health.

PRN is a leading producer of targeted nutritional supplements or nutriceuticals. PRN’s portfolio of eye health products is formulated based on a robust body of clinical evidence. That’s why thousands of top doctors recommend our products to their patients.

1.Johnson AR, Munoz A, Gottlieb JL, Jarrard DF. High dose zinc increases hospital admissions due to genitourinary complications. J Urol
2007;177:639-43. [PubMed abstract]

2. Food & Nutrition Board, Institute of Medicine. Washington D.C.: National Academies Press; 2001. [Accessed May 1, 2012]. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc; pp. 82–146.pp. 290–378.pp. 442–489. [PubMed]

AREDS2 is a registered trademark of the United States Department of Health and Human Services (HHS).

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